🧬Pre-publication genetic disease research
Pre-publication work on population prevalence and enhancing genetic diagnostics Fullscreen
🎓Master's Thesis
It's my thesis. Objective: Characterize hemoprotein binding sites (e.g. hemoglobin, cytochrome) to inform protein engineering strategies. Data was extracted/generated with Python/UCSF Chimera, analyzed/visualized with R. Results suggest nonpolar amino acids in the binding pocket may have greater importance in heme binding than previously suspected. Fullscreen
🔬🍞Stats, Streamlit🔥
Statistical analysis to identify prime candidates in a screening study. Spectrophotometry absorbance/time-series data were detrended, denoised, and statistically significant samples were identified. From thousands of samples of high-throughput data, approx. 100 candidates to move to next stage. Fullscreen
Portfolio
This Website
August 2022 - June 2023
The page you're viewing and everything besides the Streamlit iframes above are implemented using Javascript/Typescript, React, with Nextjs and a heavily edited Mantine component library.
Technologies Used:
⚛️React
TS/JS:TypeScript/JavaScript
▲Node.js/Next.js, Vercel
🔥Streamlit
Statistical Analysis/Candidate Selection
Identifying prime yeast strain candidates from a pool of approx 6000 strains. Involved time-series analysis/detrending via linear regression, ANOVA to justify pooling samples across instruments, and p-value thresholding.
Technologies Used:
🐍Python
📈plotly/statmodels/scipy/matplotlib/seaborn
🪐Google Colab/Jupyter
🔥Streamlit (~Tableau)
About my dog and me
Sherlock
He is the best. He has one white paw. A friend suggested naming him Michael Jackson.
- Rescue boi – Sherlock is, according to this adoption papers, an Australian Kelpie/Mix.
- The drama – I suspect he's part chihuahua, because he can be grouchy. Also he's smaller, and cuter than the dogs that come up in pure-bred photos.
- Mexican? – He likes spicy food and he responds better in Spanish. I'm pretty sure he was a street dog in Tucson for a while.
- Dog-shaped person – He enjoys long walks, car rides, and wearing fashionable clothing.
Pat
- Software Engineering & Bioinformatics – My MS was in Bioinformatics. I've used a number of libraries and languages to achieve results: Python, JavaScript/TypeScript, R, for visualization, Quarto, Rmarkdown, libraries like Plotly, etc.
- Pharma R&D, Wetlab – Before my Master's, I worked for 2 years in antibody formulation development. Having the science background has been invaluable in translating chemistry between empirical papers and the computational methods
- Outside work – I like cooking, gaming, skateboarding and recently I've been playing with an Arduino
- I too enjoy spicy food... like a delicious, purifying sauna: all the sweat and tears leaving my body as I nourish it.
Sherlock
